- Original Article
- Pulmonology
- Increased procalcitonin level is a risk factor for prolonged fever in children with Mycoplasma pneumonia
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Ji Eun Jeong, Ji Eun Soh, Ji Hee Kwak, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2018;61(8):258-263. Published online August 15, 2018
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Purpose: Macrolide-resistant Mycoplasma pneumoniae pneumonia (MPP) is characterized by prolonged fever and radiological progression despite macrolide treatment. Few studies have examined serum procalcitonin (PCT) level in children with MPP. We aimed to investigate the association of acute inflammation markers including PCT with clinical parameters in children with MPP. Methods: A total of 147 children were recruited. The diagnosis of MPP... |
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- Case Report
- Case of seropositive allergic bronchopulmonary aspergillosis in a 10-year-old girl without previously documented asthma
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Jeong Eun Shin, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2015;58(5):190-193. Published online May 22, 2015
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Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity lung disease due to bronchial colonization of Aspergillus fumigatus that occurs in susceptible patients with asthma or cystic fibrosis. A 10-year-old girl was referred to the Department of Pediatric Pulmonology for persistent consolidations on chest radiography. Pulmonary consolidations were observed in the right upper and left lower lobes and were not resolved with... |
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- Original Article
- Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children
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Bo Ram Cheon, Jeong Eun Shin, Yun Ji Kim, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2015;58(3):96-101. Published online March 20, 2015
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Purpose Atopic dermatitis (AD) is a chronic inflammatory relapsing skin disorder. Vitamin D plays a pivotal role in the development of AD, and interleukin (IL) 31 is known to be related to pruritus in AD. The aim of our study was to determine whether 25-hydroxyvitamin D (25(OH)D) levels are related to IL-31 levels or to the severity of AD. MethodsWe enrolled 91... |
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- Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma
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Jeong Eun Shin, Bo Ram Cheon, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2014;57(6):271-277. Published online June 30, 2014
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Purpose A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolide antibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory MP. We compared clinical features and laboratory characteristics between children with refractory MP requiring steroid treatment and those with macrolide-responsive MP and evaluated the risk factors... |
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- Case Report
- Klebsiella pneumoniae liver abscess in an immunocompetent child
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Jang-Mi Kwon, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2013;56(9):407-410. Published online September 30, 2013
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Klebsiella pneumoniae has emerged as a leading pathogen that causes pyogenic liver abscesses (PLAs) in Korea. K. pneumoniae liver abscess (KLA) is potentially life threatening, and the diagnosis is difficult. In developed countries, PLA is rarely observed in children and is frequently associated with disorders of granulocyte function and previous abdominal infection. We observed a case of KLA in a... |
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- Original Article
- Expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ in the lung tissue of obese mice and the effect of rosiglitazone on proinflammatory cytokine expressions in the lung tissue
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Seung Lok Ryu, Jae Won Shim, Duk Soo Kim, Hye Lim Jung, Moon Soo Park, Soo-Hee Park, Jinmi Lee, Won-Young Lee, Jung Yeon Shim
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Clin Exp Pediatr. 2013;56(4):151-158. Published online April 22, 2013
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Purpose We investigated the mRNA levels of peroxisome proliferator-activated receptor (PPAR)-α, PPAR-γ, adipokines, and cytokines in the lung tissue of lean and obese mice with and without ovalbumin (OVA) challenge, and the effect of rosiglitazone, a PPAR-γ agonist. MethodsWe developed 6 mice models: OVA-challenged lean mice with and without rosiglitazone; obese mice with and without rosiglitazone; and OVA-challenged obese mice with and... |
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- Successful and safe treatment of hemangioma with oral propranolol in a single institution
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Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo
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Clin Exp Pediatr. 2012;55(5):164-170. Published online May 21, 2012
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Purpose Dramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined. The objective of this study is to describe and analyze the use of propranolol as a first-line treatment or as a single therapy in management of complicated hemangioma. MethodsA retrospective chart review of eight patients... |
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- Transforming growth factor-β promoted vascular endothelial growth factor release by human lung fibroblasts
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Sang Uk Park, Joo Hwa Shin, Jae Won Shim, Deok Soo Kim, Hye Lim Jung, Moon Soo Park, Jung Yeon Shim
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Clin Exp Pediatr. 2008;51(8):879-885. Published online August 15, 2008
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Purpose : The human lung fibroblast may act as an immunomodulatory cell by providing pro-inflammatory cytokines and chemokines, which are important in airway remodeling. Vascular endothelial growth factor (VEGF) induces mucosal edema and angiogenesis. Thymus and activation regulated chemokine (TARC) induces selective migration of T helper 2 cells. We investigated whether human lung fibroblasts produced VEGF and TARC, and the... |
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- Case Report
- A case of idiopathic renal hypouricemia
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Moon Hee Han, Sang Uk Park, Deok-Soo Kim, Jae Won Shim, Jung Yeon Shim, Hye Lym Jung, Moon Soo Park
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Clin Exp Pediatr. 2007;50(5):489-492. Published online May 15, 2007
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Idiopathic renal hypouricemia is a disorder characterized by impaired urate handling in the renal tubules. This disease usually produces no symptoms, but hematuria, uric acid nephrolithiasis or acute renal failure may develop. A defect in the SLC22A12 gene, which encodes the human urate transporter, is the known major cause of this disorder. We describe a 10-month-old boy with idiopathic renal... |
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- Original Article
- Clinical features of congenital muscular torticollis
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Ji Eun Jun, Hye Kyeong Ryu, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
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Clin Exp Pediatr. 2007;50(3):241-247. Published online March 15, 2007
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Purpose : Congenital muscular torticollis (CMT) is a common and benign congenital disorder of the musculoskeletal system in neonates and infants. The pathophysiology is that the sternocleidomastoid muscle (SCM) is shortened on the involved side by fibrosis, leading to ipsilateral tilt and contralateral rotation of the face and chin. In this study, we investigated the clinical features of CMT, the... |
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- Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
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Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2006;49(8):889-894. Published online August 15, 2006
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Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the... |
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- A study of neuropeptides related to headaches in children with meningeal irritation signs
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Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
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Clin Exp Pediatr. 2006;49(5):533-538. Published online May 15, 2006
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Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We... |
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- The significance of vascular endothelial growth factor(VEGF) in children with asthma and pneumonia
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Seong Hwan Choi, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2006;49(2):192-197. Published online February 15, 2006
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Purpose : Vascular endothelial growth factor(VEGF) is a key cytokine for controlling vascular permeability and angiogenesis, which is one of the major findings in airway remodeling. However, it is not well known if it is associated with acute lower respiratory tract disease such as lobar pneumonia. The aim of this study is to compare serum VEGF levels in patients with... |
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- A clinical study of migraines without aura in children : based on revised international headache society criteria
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Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-soo Kim
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Clin Exp Pediatr. 2006;49(1):71-75. Published online January 15, 2006
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Purpose : Because migraine in children has different characteristics from that in adults, it is inappropriate to apply migraine criteria for adults to children. Recently, the International Headache Society(IHS) revised criteria regarding children's characteristics. Therefore, we reviewed the characteristics of childhood migraines without auras based on the revised criteria and compared the data with the findings of childhood migraine by... |
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- Case Report
- Two Cases of Lead Poisoning due to Herb Medicinal Pills
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Seong Hwan Choi, Eun Young Park, Jung Yeon Shim, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2005;48(9):1009-1015. Published online September 15, 2005
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We encountered two children with lead poisoning who were administered herb medicinal pills recommended by their clergyman. These patients presented anemia and severe coliky abdominal pain, but no neurologic symptoms. For this reason, they were initially misdiagnosed with gastrointestinal hemorrhagic disease. However, we got a clue that they took herb medicinal pills. Finally, based on the assay of blood lead... |
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- Original Article
- Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
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Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2005;48(3):284-291. Published online March 15, 2005
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Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In... |
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- Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and
IGFBP-3 Levels in Healthy Korean Children
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Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
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Clin Exp Pediatr. 2005;48(3):298-305. Published online March 15, 2005
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Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex.
Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;... |
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- Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
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Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
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Clin Exp Pediatr. 2005;48(1):48-54. Published online January 15, 2005
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Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports... |
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- Serum Vascular Endothelial Growth Factor as a Predictive Risk Factor for the Occurrence of
Coronary Artery Lesions in Kawasaki Disease
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Min Hyuk Park, Hye Lim Jung, Ju Hee Yang, Jung-Yeon Shim, Deok Soo Kim, Jae Won Shim, Moon Soo Park
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Clin Exp Pediatr. 2003;46(8):811-816. Published online August 15, 2003
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Purpose : Kawasaki disease is an acute systemic vasculitis of unknown etiology with a predilection for the coronary arteries. Vascular endothelial growth factor(VEGF) is a cytokine which promotes vascular permeability and angiogenesis. We investigated serum VEGF(sVEGF) levels in Kawasaki disease to determine whether sVEGF level can be used as a risk factor to predict the occurrence of coronary artery lesions(CAL)... |
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- Increased Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 Levels in the Cerebrospinal Fluid from Children with Aseptic Meningitis
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Ju Hee Yang, Min Hyuk Park, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuck Keum
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Clin Exp Pediatr. 2003;46(6):548-553. Published online June 15, 2003
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Purpose : Matrix metalloproteinase(MMP)-9 is known to breakdown the blood-brain barrier by degrading the extracellular matrix of the subendothelial basement membrane in meningitis. Tissue inhibitor of metalloproteinase(TIMP)-1, a known inhibitor of MMP-9, has been postulated to inhibit the proteolytic activity of MMP-9 by bindng to MMP-9, but their interaction has not been fully understood yet. So far, there have been... |
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- Case Report
- Two Cases of Gitelman's Syndrome Diagnosed by
Renal Clearance Study
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Tae Hwa Kim, Seung Jun Kim, Yu Kyung Seo, Jung-Yeon Shim, Hye Lim Jung, Moon Soo Park, Dong Hyuk Kum
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Clin Exp Pediatr. 2002;45(3):413-417. Published online March 15, 2002
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Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. In this study, we performed renal clearance studies to differentiate Gitelman's from Bartter's syndrome and to confirm the diagnosis in two patients clinically diagnosed with Gitelman's syndrome. Each patient was hydrated... |
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- Original Article
- A Seroepidemiologic Study on Hepatitis A in Seoul, Korea
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Dong Woon Yang, Young Ah Lee, Jung Yeon Shim, Jin Young Park, Hye Lim Jung, Moon Soo Park, Dong Hyeuk Keum
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Clin Exp Pediatr. 1999;42(2):180-185. Published online February 15, 1999
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Purpose : The prevalence of hepatitis A(HAV) in a certain community reflects that community’s living standard and hygienic condition. And the pattern of HAV infection differs over time and geography, with varying widely from country to country and even within the same city. Recently a shift in prevalence has been observed in cases from childhood to adulthood. We studied HAV... |
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- Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
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Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
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Clin Exp Pediatr. 1999;42(12):1676-1682. Published online December 15, 1999
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Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated... |
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- Acute Renal Failure in Children : Underlying Disease and Management according to Age
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Eun Joung Park, Joung Sim Kim, Jai Bok Yoo, Joung Sook Sul, Si Whan Koh, Phil Soo Oh, I Suk Kang, Moon Soo Park, Heung Jae Lee, Dong Kyoo Jin
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Clin Exp Pediatr. 1998;41(5):654-662. Published online May 15, 1998
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Purpose : It has been stressed that age itself as well as multiple organ failure are important prognostic factors in acute renal failure(ARF) in children. This study was performed to find out the significance of age factor and underlying disease of ARF in children.
Methods : We tried to review 58 pediatric ARF cases, retrospectively, in the pediatric intensive care unit(excluding... |
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- The Prevalence of A985G Mutation in Medium Chain Acyl-Coenzyme A Dehydrogenase(MCAD) Gene in Neonates Determined from Guthrie Card
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Baeck Hee Lee, Hye Won Park, Moon Soo Park, Ho Jin Park, Yong Choi, Hae Il Cheong
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Clin Exp Pediatr. 1997;40(12):1645-1650. Published online December 15, 1997
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Purpose : Medium chain acyl-CoA dehydrogenase(MCAD) deficiency is an autosomal recessive
disoder of β oxidation of fatty acids and characterized by episodic hypoglycemia, vomiting,
convulsion, encephalopathy, apnea, and sudden death related to fasting or infection resembling Reye
syndrome or sudden infant death syndrome. In acute stage, mortality rate is very high and
survivors have significant risk of developmental disability and chronic somatic illness. However,... |
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- Case Report
- A Case of17α-Hydroxylase Deficiency
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Yong Kyu Lee, Yun Jong Kang, Chan Young Pak, Soo Young Choi, Moon Soo Park
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Clin Exp Pediatr. 1996;39(4):577-584. Published online April 15, 1996
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A 12-year-old girl with hypertension, hypokalemia, cystic ovaries and absence of secondary sexual development is presented. Hormonal study revealed very low levels of cortisol, testosterone, estrogen, and high levels of progesterone, deoxycorticosterone, corticosterone, FSH and ACTH. Following treatment with dexamethasone and estrogen, the levels of the latter group remarkably decreased. Serum potassium level and blood pressure also became normal. With... |
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- Original Article
- A case of idiopathic precocious puberty treated with a luteinizing hormone relaeasing hormone analog.
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Keun Hee Chung, Yoo Mi Kim, Mi Won Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang
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Clin Exp Pediatr. 1991;34(8):1132-1138. Published online August 31, 1991
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We experienced a 4 year girl with idiopathic precocious puberty treated with a long acting LHRH
analog (Buserelin). As an indction therapy she received LHRH analog for 6 months in subcutaneous
route. After then she was maintained by intranasal therapy for 6 months. One month after the
induction therapy began, we observed prepunbertal pattern of LHRH stimulation test and significant
suppression of 17B-estradiol level.... |
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- A Case of Acute Interstitial Nephritis Associated with Yersinia Pseudotuberculosis Infection.
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Keun Hee Chung, Yoo Mee Kim, Mee Won Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang
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Clin Exp Pediatr. 1990;33(8):1123-1128. Published online August 31, 1990
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Authors recently experienced a case of acute interstitial nephritis associated with Yersinia
pseudotuberculosis infection in 10-8/12 year old boy, who was admitted to prolonged high fever. On
3rd hospital day, puffy face and oliguria were noted. BUN and serum creatinine rose to peak level,
94.1 mg/dl and 10.1 mg/dl, respectively on 7th hospital day. After then renal functions were normal-
ized gradually without specific... |
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- A case of Erythema Nodosum due to Yersinia Pseudotuberculosis.
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Keun Hee Chung, Hong Jong Joo, Yoo Mi Kim, Soon Ki Kim, Moon Soo Park, Jin Keun Chang, Sung Woo Shin
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Clin Exp Pediatr. 1990;33(4):528-533. Published online April 30, 1990
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Yersinia pseudotuberculosis infection is one of the common causes of erythema nodosum in Europe,
but in Korea only 2 cases have been reported. Recently authors experienced a 6 year old boy who
suffered from erythematous painful skin lesions on the shin and calf, and was diagnosed serologically
as erythema nodosum due to Yersinia pseudotuberculosis infection. So we report here the clinical
findings of this... |
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- An Outbreak of Yersinia pseudotuberculosis Infection.
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Hong Jong Joo, Keun Hee Chung, Yoo Mee Kim, Soon Gi Kim, Moon Soo Park, Jin Keun Chang, Sung Woo Shin
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Clin Exp Pediatr. 1990;33(3):341-350. Published online March 31, 1990
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We experienced one outbreak of Yersinia pseudtuberculosis infection that had not been reported in
our country.
In May, 1988, an outbreak of acute infection with symptoms suggestive of Yersinia pseudotuber-
culosis infection occurred among a middle school students in No-Won-Gu, Seoul.
Two hundreds and fifteen students went on a picnic at the Mt. Surak in No-Won-Gu on 13th May,
1988. Fifty of 95 students who... |
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- Two Cases of Idiopathic Hypercalciuria in Children.
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Joon Cho, Hye Lyung Baik, Hong Jong Joo, Jin Keun Chang, Moon Soo Park, Sung Woo Shin
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Clin Exp Pediatr. 1988;31(5):635-640. Published online May 31, 1988
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We herein experienced two cases of idiopathic hypercalciuria in a 4 year old boy and 8 year old boy
who had asymptomatic gross hematuria.
Diagnosis was made by a urinary calcium excretion of more than 4 mg per kilogram of body weight
per 24 hours and by a urinary calcium-creatinine ratio of more than 0.21, under situation that specific
etiology of hypercalciuria was not... |
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- Case Report
- A Case of "Cri-du-Chat" Syndrome.
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Hye Lyung Baik, Gui Sook Choi, Joon Cho, Moon Soo Park, Jin Keum Chang, Sung Woo Shin, Shin Yong Moon
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Clin Exp Pediatr. 1987;30(3):309-313. Published online March 31, 1987
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A case of Cri-du-Chat syndrome was presented which was characterized by typical cat cry, staring
gaze and other common deletion syndrome.
The karyotype of it was proved to be 46, XY, (5p_) and a brief review was added for this case.
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- Original Article
- A Clinical and Pathological Study of Recurrent Hematuria in Chilhood.
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Moon Soo Park, Kwang Wook Ko
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Clin Exp Pediatr. 1982;25(6):571-583. Published online June 30, 1982
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The clinical, laboratory, and renal biopsy finding in 22 chilren with recurrent hematuria are presented. 1.The mean age at oneset was 7 6/12 years, and male to female ratio was 1.8:1. The gross hematuric attack was preceded by upper respiratory infection in 15 cases(68%), while strenuo-us exercise in 10 cases(45%). Loin pain was accmpanied with gross hematuria in 4 cases(18%).... |
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